04/04/2019 - Press release
Doctors and researchers at Hospital del Mar and the Hospital del Mar Medical Research Institute (IMIM) have shown, for the first time, that osteoporosis and bone fractures in HIV sufferers is caused by the body's response to the presence of the virus, in the form of inflammatory processes, and not only the antiretroviral treatment, as was previously believed. The study, published in the Journal of Antimicrobial Chemotherapy, used a bone-quality measuring technique designed in the United States in collaboration with staff from Hospital del Mar, together with a protocol developed by the same people, which shows that the risk of fractures is related to the inflammation caused by the chronic infection. This represents a change in how this problem is conceived, as well as how it is approached. The study involved staff from the Infectious Diseases and Internal Medicine services at Hospital del Mar, as well as members of the IMIM's Musculoskeletal Research Group. Dr. Todd T. Brown, from Johns Hopkins University, in the United States, also participated.
Més informació "Paradigm shift in how bone fractures are avoided in HIV patients"
03/04/2019 - Press release
In general, the creation of parks and green spaces in urban centers has positive effects on the health of city residents. However, looking in more detail, only those who belong to the most favored social classes may be benefitting from these spaces. A new article published by a group of researchers from the Institut de Ciència i Tecnologia Ambientals of the Universitat Autònoma de Barcelona (ICTA-UAB) and the Medical Research Institute of the Hospital del Mar (IMIM) shows that, although living in areas with green spaces are associated with better self-perceived health on the part of residents at large, such benefits exclude those with a lower educational level and lower incomes. The progressive "greening" of cities through the creation of green spaces, parks and ecological corridors can have positive effects on the physical and psychological health of people.
Més informació "Urban green spaces do not benefit the health of all"
29/10/2018 - Press release
The study, published in the journal Cancer Research, shows the pivotal role of the enzyme USP27X in the control of the proliferation, invasion and formation of breast cancer metastasis and opens new pathways to the development of anti-tumour drugs. A team of researchers from the Cancer programme of the Hospital del Mar Medical Research Institute (IMIM), led by Drs Victor M. Diaz, of Pompeu Fabra University (UPF) and Antonio García de Herreros, of the IMIM, has identified a key enzyme in cancer development called USP27X.
Més informació "Discovery of a key protein in tumour metastasis"
22/03/2019 - Institutional news
In relation to the HOSPITAL RESOURCES DIRECTOR OF HUMAN RESOURCES Institut Mar d'investigacions Mèdiques Foundation, managing entity of the Hospital del Mar Institute for Medical Research. (call FIMIM_01 / 2019), the deadline for submitting candidatures is extended until March 28, 2019.
18/02/2019 - Institutional news
The Mar Institute of Medical Research Foundation (IMIM Foundation), announces the position of Director with incorporation through a full-time work contract and appointment as Director. The person awarded the position will be responsible for developing and implementing policies related to staff effectiveness, aligned with the Institute's strategy. Their main role will be to ensure that the people who work in the Institute have a balance between skills and experience, fostering their development so that they have the opportunity to improve their position within the Institute itself. They must always generate a supportive and challenging work environment that promotes equal opportunities, ethical integrity, and a work-life balance.
19/11/2018 - Press release
Having certain specific variants of the PATJ gene predisposes to worse recovery from ischemic stroke. 7 out of 10 patients with these variants suffer severe sequelae three months after having a stroke, in other words, they are in a situation of dependence, compared to less than half of patients who do not present these variants. This is data from an international, multicentre study coordinated by researchers at the Hospital del Mar Medical Research Institute (IMIM) and doctors from the Hospital del Mar, published in the journal Circulation Research. This is the most important research carried out so far in the field of genetics and stroke prognosis, and the first published: it uses data from more than 2,000 patients and involves 12 centres from around the world. The study was carried out thanks to the help of the 2010 edition of La Marató de TV3.
Més informació "Gene vital for post-stroke recovery identified for the first time"
02/08/2018 - Press release
Inhibiting the Jagged 1 protein in mice prevents the proliferation and growth of colon and rectal tumours. What is more, this approach to the disease permits the removal of existing tumours. This is the conclusion of a study led by the Molecular Mechanisms of Cancer and Stem Cells research group from the Hospital del Mar Medical Research Institute (IMIM), directed by Dr Lluís Espinosa, who is also a member of CIBERONC (the Network Centre for Biomedical Research into Cancer), in collaboration with the Pathological Anatomy and Medical Oncology Units at Hospital del Mar, and the IDIBELL-Catalan Oncology Institute. The work has been published in Nature Communications. The researchers took tumours from patients and then implanted them into mice in order to analyse the role of this protein in cancer cell proliferation. Jagged 1 is essential for cancer cells due to its role in activating the so-called Notch cell-signalling pathway. Generally speaking, Notch inhibits cell differentiation, in other words, a cell's ability to become a mature cell that can no longer proliferate. In the case of colorectal tumours, the activation of this signalling pathway favours their proliferation and growth.
Més informació "Key piece identified for slowing a colorectal cancer subtype"
11/07/2018 - Press release
Researchers led by Emre Guney of the research programme on Biomedical Informatics (GRIB), a joint programme of Pompeu Fabra University (UPF) and the Hospital del Mar Medical Research Institute (IMIM), have developed a new computational method to reuse drugs that target biological pathways common to more than one disease. A significant percentage of marketed drugs are not effective in patients due to the complexity of the biological processes involved in diseases and genetic differences between people. Despite recent technological advances, the discovery of new effective treatments takes a long time and continues to be expensive. For this reason, the reuse of medicines, i.e., the use of existing drugs for other diseases, is a very interesting alternative to reduce the costs of drug development.
Més informació "A new computational method for exploring the reuse of drugs"
10/07/2018 - Institutional news
On June 8th, Dr Jordi Mestres, coordinator of the IMIM Systems Pharmacology Research Group, was elected Fellow of the Royal Society of Chemistry of the United Kingdom. Achieving this status is an important milestone in a researcher's career as it indicates scientific quality and is one of the most important recognitions a chemist can receive. The Royal Society of Chemistry is a non-profit organisation that is more than 175 years old and has more than 54,000 members across the world. Its aim is to advance excellence in the chemical sciences, investing in the education of future generations, creating and maintaining standards, encouraging innovation, and advising governments.
Més informació "Jordi Mestres elected Fellow of the Royal Society of Chemistry"
Immunotherapy, the use of the patient's own immune system to attack tumour cells is the method chosen by the Hospital del Mar and its research centre, the Hospital del Mar Medical Research Institute (IMIM) in their search for new breast cancer treatments. They are looking in particular at triple negative breast cancer, one of the most aggressive types, which, in addition, affects younger patients and is the breast tumour with the fewest therapeutic targets for oncologists. This commitment has received a strong boost thanks to the grant the Cancer Research Institute (CRI) has just awarded the project "LCOR orchestrates the differential IFN-a response and immunological properties of triple-negative breast cancer cells", led by Dr. Toni Celià-Terrassa, a researcher in the Molecular Therapy of Cancer group, directed by Dr. Joan Albanell, head of medical oncology at Hospital del Mar and director of the IMIM's Cancer Research programme.
Més informació "Immunotherapy for treating the most aggressive breast cancer"
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