New computational tool to improve prediction of the genetic impact on diabetes and obesity

07/10/2026

The GLP-1 receptor is a protein that responds to GLP-1, a naturally occurring hormone that regulates blood sugar levels and feelings of satiety. It is therefore the target of some of the most advanced and widely used treatments currently available for type 2 diabetes and obesity, such as Ozempic. For this reason, understanding how the function of this receptor may vary depending on genetic changes affecting it is particularly important.

Individuals can naturally carry different genetic variants of the GLP-1 receptor, known as GLP1R variants. The individual risk of developing type 2 diabetes and variability in response to treatment may differ depending on the presence of a particular variant.

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