Seeds of Metastasis Identified: A New Target to Prevent Breast Cancer Metastasis Before It Emerges

10/07/2025

The journal Cancer Cell has published a study led by the Hospital del Mar Research Institute, together with researchers from GEICAM, identifying malignant cells carrying the TIM-3 protein as a central factor in their ability to generate breast cancer metastasis.

This molecule allows cancer cells to survive the most critical and challenging stage of metastasis-when they first reach a new organ-by evading immune system attacks. At the same time, it may serve as a marker of poor prognosis and metastasis risk in patients with TIM-3-positive tumors.

This discovery opens the door to the potential use of treatments that block TIM-3 to prevent metastasis before it becomes clinically evident.

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