09/02/2024 - Press release
An international study has used a computational biology tool that, by analysing a multitude of biological data from multiple sclerosis patients ranging from genetic information to the whole organism, reveals the relationship between elements of different biological scales and improves our knowledge and the diagnosis of the disease. International research led by the Department of Medicine and Life Sciences (MELIS) at Pompeu Fabra University, in collaboration with Hospital del Mar, Hospital Clínic, Charité - Medical University of Berlin, and the universities of Oslo and Genoa, has developed a computational biology tool, based on multi-level network analysis, to achieve an integrated vision of multiple sclerosis. This tool could be used to study other complex diseases such as types of dementia.
30/01/2024 - Press release
This is revealed by the largest observational study in this field carried out to date in the world. It is published in the journal Nutrients. The work is based on data from the UK Biobank database and has made it possible to analyze information from more than 260,000 people. Its conclusions may allow a more detailed definition of future studies on omega-3 supplementation for the prevention of dementia. The potential benefits of these fatty acids are maximal in men over 60 and in dementias other than Alzheimer's disease.
10/01/2024 - Press release
Functional alterations in the brains of individuals with this condition coincide with the distribution of these neurons in the same brain. These neurons are responsible for filtering external information reaching the brain. Their functioning is altered in individuals with schizophrenia, which explains the majority of their symptoms. This discovery is the first time that this alteration can be identified as a possible origin of schizophrenic symptoms, and it opens the door to seeking new targeted treatments with fewer patient side effects.
28/12/2023 - Press release
An observational study conducted by researchers from Pompeu Fabra University and Hospital del Mar determines that the intradermal administration of the JYNNEOS vaccine against smallpox induces an efficient immune response that should protect people living with HIV from contracting the monkeypox virus.
Researchers from the Hospital del Mar Research Institute have published a new article in Microbiology Spectrum proposing a novel approach to treating pneumonia caused by antibiotic-resistant Pseudomonas aeruginosa bacteria. The study suggests that increasing the dose of the antibiotic colistin may not only be ineffective, but could also increase patient mortality. For this reason, the researchers advocate for using nebulized administration of the treatment instead of intravenous administration. This approach achieves higher concentrations in the lungs, where the infection is located, without causing toxic colistin concentrations in the blood. The World Health Organization considers antibiotic resistance among the top 10 global public health threats.
A study involving the Hospital del Mar Research Institute, the Vall d'Hebron Institut d'Oncologia, IDIBELL, and the Institut Català d'Oncologia suggests that combining chemotherapy with drugs that can inhibit two cell signaling pathways involved in tumor progression may aid in treatment. The research has analyzed the interaction of the protein IKKα with these pathways, known for their ability to promote the proliferation of tumor cells. This combination has the advantage of reducing treatment toxicity. The study opens the door to new approaches for tumors with the presence of this protein. It is published in the EMBO Journal.
Més informació "A possible new combination of treatments to combat cancer"
05/10/2023 - Press release
A study led by researchers at the Hospital del Mar Research Institute identifies that the deterioration of the blood-brain barrier, which regulates exchanges between the blood and the brain, can be used to identify which of these patients will have a more rapid progression. In the patients analysed, the risk of accelerated disease progression increases by 8% for every 10% increase in the level of albumin in cerebrospinal fluid and blood (a biomarker of damage to the blood-brain barrier). The results indicate that restoring the blood-brain barrier's ability to protect the brain could help slow the worsening of patients. This marker will allow a more accurate assessment of the prognosis of patients with cognitive impairment caused by Alzheimer's and other dementias. The work is published in the journal Alzheimer's&Dementia.
27/09/2023 - Press release
Research conducted in a mouse model identifies the neurobiological mechanism responsible for alterations in the memory of young individuals exposed to alcohol during pregnancy and lactation. This study proposes a therapy that can reverse the deficit, paving the way for treating a disorder that is underdiagnosed in humans.
18/09/2023 - Press release
Researchers from the UAB, the Gregorio Marañón Health Research Institute, and the Hospital del Mar Research Institute have published the first article reviewing research conducted to date on the neurobiological adaptation of women to motherhood by analysing the relation of hormones, brain and behaviour during pregnancy and the postpartum period.
17/08/2023 - Press release
This is highlighted in a study published in Diabetes Metabolism Research and Reviews, sponsored by the Erasmus University of Rotterdam, the Hospital del Mar and the Hospital del Mar Research Institute. The paper highlights the role of glycans, the sugars that envelop one of the most common blood antiglycans, immunoglobulin G. Depending on their combination, patients' prognosis changes and they are more likely to present microvascular complications, such as nephropathy, or macrovascular, such as cardiac problems. This environment can be modified by changes in lifestyle and diet. This fact makes it a potential therapeutic target.
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