09/05/2019 - General information
The GRIB Integrative Biomedical Informatics group (IMIM-UPF) has launched a new version of DisGeNET, a public knowledge management platform on the genomics of disease, which is celebrating its tenth anniversary this year. DisGeNET offers information on genes and genomic variants associated with human diseases, which is obtained by integrating more than a dozen public resources and the scientific literature. DisGeNET contains one of the most comprehensive collections of genes and variants associated with human diseases that is currently available. The new version of DisGeNET (6.0) contains approximately 600,000 associations between more than 17,000 genes and 24,000 human diseases, focusing particularly on genetic alterations associated with disease: this version includes more than 117,000 genomic variants associated with 10,000 diseases. In addition, the phenotypic landscape covered by DisGeNET has been expanded to include the genomic basis of clinical manifestations of diseases, both signs and symptoms, as well as laboratory tests results.
Més informació "New version of DisGeNET 6.0 and ELIXIR recognition"
10/04/2019 - General information
The project EOSC-Life aims to create an open collaborative digital space for life science in the European Open Science Cloud (EOSC). EOSC-Life brings together the 13 european research infrastructures in the Health and Food domain of the ESFRI Roadmap and is funded by H2020 for the period 2019-2023. The project involves research groups from 46 European academic institutions. These include the GRIB Systems Pharmacology research group (IMIM-UPF) led by Jordi Mestres, which is helping develop collaborative tools for integrating and analysing all kinds of data in the field of life sciences.
05/04/2019 - Institutional news
Provisional relationship of advice and excluded aspirant persons that have been submitted to the external call for the merits competition, for the provision of a job of HUMAN RESOURCES DIRECTOR Mar Institute of Medical Research Foundation Managing body of the Hospital del Mar Medical Research Institute (IMIM) (Call FIMIM_01/2019).
04/04/2019 - Press release
Doctors and researchers at Hospital del Mar and the Hospital del Mar Medical Research Institute (IMIM) have shown, for the first time, that osteoporosis and bone fractures in HIV sufferers is caused by the body's response to the presence of the virus, in the form of inflammatory processes, and not only the antiretroviral treatment, as was previously believed. The study, published in the Journal of Antimicrobial Chemotherapy, used a bone-quality measuring technique designed in the United States in collaboration with staff from Hospital del Mar, together with a protocol developed by the same people, which shows that the risk of fractures is related to the inflammation caused by the chronic infection. This represents a change in how this problem is conceived, as well as how it is approached. The study involved staff from the Infectious Diseases and Internal Medicine services at Hospital del Mar, as well as members of the IMIM's Musculoskeletal Research Group. Dr. Todd T. Brown, from Johns Hopkins University, in the United States, also participated.
Més informació "Paradigm shift in how bone fractures are avoided in HIV patients"
03/04/2019 - Press release
In general, the creation of parks and green spaces in urban centers has positive effects on the health of city residents. However, looking in more detail, only those who belong to the most favored social classes may be benefitting from these spaces. A new article published by a group of researchers from the Institut de Ciència i Tecnologia Ambientals of the Universitat Autònoma de Barcelona (ICTA-UAB) and the Medical Research Institute of the Hospital del Mar (IMIM) shows that, although living in areas with green spaces are associated with better self-perceived health on the part of residents at large, such benefits exclude those with a lower educational level and lower incomes. The progressive "greening" of cities through the creation of green spaces, parks and ecological corridors can have positive effects on the physical and psychological health of people.
Més informació "Urban green spaces do not benefit the health of all"
29/10/2018 - Press release
The study, published in the journal Cancer Research, shows the pivotal role of the enzyme USP27X in the control of the proliferation, invasion and formation of breast cancer metastasis and opens new pathways to the development of anti-tumour drugs. A team of researchers from the Cancer programme of the Hospital del Mar Medical Research Institute (IMIM), led by Drs Victor M. Diaz, of Pompeu Fabra University (UPF) and Antonio García de Herreros, of the IMIM, has identified a key enzyme in cancer development called USP27X.
Més informació "Discovery of a key protein in tumour metastasis"
22/03/2019 - Institutional news
In relation to the HOSPITAL RESOURCES DIRECTOR OF HUMAN RESOURCES Institut Mar d'investigacions Mèdiques Foundation, managing entity of the Hospital del Mar Institute for Medical Research. (call FIMIM_01 / 2019), the deadline for submitting candidatures is extended until March 28, 2019.
18/02/2019 - Institutional news
The Mar Institute of Medical Research Foundation (IMIM Foundation), announces the position of Director with incorporation through a full-time work contract and appointment as Director. The person awarded the position will be responsible for developing and implementing policies related to staff effectiveness, aligned with the Institute's strategy. Their main role will be to ensure that the people who work in the Institute have a balance between skills and experience, fostering their development so that they have the opportunity to improve their position within the Institute itself. They must always generate a supportive and challenging work environment that promotes equal opportunities, ethical integrity, and a work-life balance.
19/11/2018 - Press release
Having certain specific variants of the PATJ gene predisposes to worse recovery from ischemic stroke. 7 out of 10 patients with these variants suffer severe sequelae three months after having a stroke, in other words, they are in a situation of dependence, compared to less than half of patients who do not present these variants. This is data from an international, multicentre study coordinated by researchers at the Hospital del Mar Medical Research Institute (IMIM) and doctors from the Hospital del Mar, published in the journal Circulation Research. This is the most important research carried out so far in the field of genetics and stroke prognosis, and the first published: it uses data from more than 2,000 patients and involves 12 centres from around the world. The study was carried out thanks to the help of the 2010 edition of La Marató de TV3.
Més informació "Gene vital for post-stroke recovery identified for the first time"
02/08/2018 - Press release
Inhibiting the Jagged 1 protein in mice prevents the proliferation and growth of colon and rectal tumours. What is more, this approach to the disease permits the removal of existing tumours. This is the conclusion of a study led by the Molecular Mechanisms of Cancer and Stem Cells research group from the Hospital del Mar Medical Research Institute (IMIM), directed by Dr Lluís Espinosa, who is also a member of CIBERONC (the Network Centre for Biomedical Research into Cancer), in collaboration with the Pathological Anatomy and Medical Oncology Units at Hospital del Mar, and the IDIBELL-Catalan Oncology Institute. The work has been published in Nature Communications. The researchers took tumours from patients and then implanted them into mice in order to analyse the role of this protein in cancer cell proliferation. Jagged 1 is essential for cancer cells due to its role in activating the so-called Notch cell-signalling pathway. Generally speaking, Notch inhibits cell differentiation, in other words, a cell's ability to become a mature cell that can no longer proliferate. In the case of colorectal tumours, the activation of this signalling pathway favours their proliferation and growth.
Més informació "Key piece identified for slowing a colorectal cancer subtype"
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