10/08/2023 - Press release
A team from the Hospital del Mar Research Institute has, for the first time, detected fetal DNA in the olfactory neuroepithelium of women who have given birth to a boy. A new study will now be launched, which will also analyze female fetal DNA. The team of researchers has been able to confirm that women with depression had much lower levels of cells from newborns than those who were not suffering from this disorder. This discovery paves the way to studying the DNA exchange between the mother and the fetus during pregnancy as a factor that protects women against depression, as well as its relationship with other psychiatric disorders.
28/07/2023 - Press release
Cannabis use disorder (CUD) affects over 14 million individuals in the US.? Despite the urgent need, there are no FDA-approved medications to treat CUD; behavioral treatments have shown limited benefit. AEF0117 is the first of a new pharmacologic class, type 1 cannabinoid receptor signaling-specific inhibitors (CB1-SSi), with a unique mechanism of action and greater safety and efficacy than prior generations of CB1 inhibitors.? In a phase 2a clinical study in volunteers with CUD, AEF0117 produced statistically significant reductions in the positive subjective and reinforcing effects of smoked cannabis.
14/07/2023 - Press release
The prevalence of childhood obesity is higher among male participants (14.9%) and in the population aged 8 to 12 years (15.6%). It is confirmed once again that the childhood obesity epidemic in Spain presents a socioeconomic gradient: children enrolled in schools with a lower average income per person have a higher level of obesity. The Gasol Foundation study, carried out with the support of the Hospital del Mar Research Institute, shows a deterioration in eating habits, use of screens, hours of sleep, physical activity, emotional well-being and quality of life among children aged 8 to 16 years in Spain.
21/06/2023 - Press release
The Molecular Mechanisms of Cancer and Stem Cell Research Group of the Hospital del Mar Research Institute is the only center in Spain to participate in an international study that validates the deficiency of a protein, IκBα, as a marker of poor prognosis in this type of tumor The work, published in Cell Reports Medicine, has analyzed data from more than 2,000 patients. In addition, the researchers have identified one of the pathways on which this protein acts, which makes it a possible therapeutic target The Hospital del Mar Research Institute group is already working on a model to search for possible treatments that modulate the function of this marker. It should be considered that at present there are very few therapeutic alternatives for glioma, which has a very high mortality rate
15/06/2023 - Press release
A study published in iScience, spearheaded by the Hospital del Mar Research Institute and the Barcelonaβeta Brain Research Centre, part of the Pasqual Maragall Foundation, validates these tools for monitoring potential sufferers. Data was analysed from 56 volunteers who participated in the PENSA study, designed to determine whether it is possible to slow cognitive decline in stages prior to the onset of dementia through a combination of a lifestyle intervention programme and the consumption of a preparation based on a green tea component. It was possible to monitor the evolution of the cognitive functions of these people much more closely and continuously than with standard tests. This paves the way for the adaptation, practically in real time, of treatments that can be adjusted to changes in cognitive decline.
30/03/2023 - Press release
Adding a peptide, a molecule made of several amino acids, to oxaliplatin, a chemotherapy drug used to treat colorectal cancer, avoids the side effects this treatment can have on normal cells, including potential chemotherapy resistance. This is confirmed by an article published in the Journal of Medicinal Chemistry, led by the Hospital del Mar Medical Research Institute and the Institute for Research in Biomedicine (IRB Barcelona). This work is the second part of a recent study that explored how platinum accumulation in normal cells promotes platinum resistance in colorectal cancer cells. This new approach prevents healthy cells surrounding the tumour from accumulating platinum. This avoids the activation of certain genes linked to poor treatment response and tumour progression.
01/03/2023 - Press release
Low levels of a particular protein in squamous cell carcinoma cells indicate that they are preparing to start migrating to other organs, thereby causing the tumour to spread to other areas of the body. This is according to a study by the Hospital del Mar Medical Research Institute, which has just been published in the journal Life Science Alliance. Tumour cells prepare to migrate by changing their metabolism so that they can consume lipids, in other words, cholesterol molecules. This raises the possibility of studying ways to block this process and prevent tumour metastasis.
Més informació "Marker discovered that shows when a type of skin cancer is preparing to metastasise"
21/02/2023 - Press release
A study led by researchers at the Hospital del Mar Medical Research Institute shows that the oxaliplatin administered in some cases of colorectal cancer accumulates in non-cancerous/healthy cells from the tumor environment. This accumulation causes healthy cells to produce a protein that further activates them, triggering tumor resistance to treatment and assisting in tumor regeneration. The researchers discovered a marker that can identify these tumors unresponsive to chemotherapy. The study, published in the journal Nature Communications, paves the way for new strategies enhancing the effects of chemotherapy on cancer cells while avoiding adverse side effects on non-cancerous cells.
20/01/2023 - Press release
A person's biological age, in other words, the real age of their body, which is independent of chronological age and which can be measured in specific blood tests, is conditioned by their lifestyle habits. A study by the Neurovascular Research Group at the Hospital del Mar Medical Research Institute, published in the journal Biology, has for the first time associated a higher biological age with the presence of an indicator of brain ageing, white matter hyperintensities, areas of the brain that blood has a harder time reaching. Lifestyle habits influence the DNA configuration and determine biological age. If these habits are modified, DNA ageing and, therefore, biological ageing can be slowed down, thereby decelerating the increase in white matter hyperintensities in brain tissue.
11/01/2023 - Press release
A study led by researchers from the Stem Cell and Cancer Research Group at the Hospital del Mar Medical Research Institute has revealed the key role a protein plays in identifying patients with T-cell acute lymphoblastic leukaemia who will not respond to standard treatment. The study, published in the journal EMBO Molecular Medicine, shows that combining chemotherapy with an inhibitor for this protein helps to eliminate treatment resistance in an animal model. This is a rare disease, which is diagnosed in around a hundred people each year in Spain, mainly paediatric patients.
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