11/08/2022 - Press release
The research, led by the Barcelonaβeta Brain Research Center (BBRC), research center of the Pasqual Maragall Foundation, the Hospital del Mar Medical Research Institute (IMIM-Hospital del Mar) and the University of Gothenburg, has been published in the prestigious journal Nature Medicine. The study, which used data from almost 400 participants of the ALFA+ Study, which has the impetus of the "la Caixa" Foundation, determines that the biomarkers p-tau231 and p-tau217 measured in the blood are suitable for indicating brain changes related to the amyloid protein in people without cognitive symptoms. The results of this research make p-tau231 a very promising blood biomarker to detect early those middle-aged people who show the first brain changes associated with Alzheimer's and to conduct clinical trials aimed at this early stage of Alzheimer's.
28/07/2023 - Press release
A study by cardiologists at Hospital del Mar and researchers at the Hospital del Mar Medical Research Institute reveals that more than half of the people treated for the arrhythmia known as atrial flutter will suffer an episode of atrial fibrillation in less than a year. The risk of atrial fibrillation reaches 86% in those patients who score higher on a risk scale designed by the team, prompting the need for more accurate monitoring of these patients because of the likelihood that they could suffer other cardiovascular problems, such as a stroke. The study, published in the Journal of Cardiology, was funded by the 2014 La Marató de TV3, dedicated to heart disease.
Més informació "Patients with arrhythmia are at greater risk of suffering atrial fibrillation"
30/05/2022 - Press release
A group of genes has been identified in cancerous cells that survive chemotherapy treatment. The activity of these genes leads to treatment resistance and increased capacity for metastasis. This breakthrough opens the door to studying targeted treatments using drug inhibitors of these genes combined with chemotherapy, potentially providing alternatives for patients with a worse prognosis in this type of tumor, accounting for 30% of cases. The research, led by scientists from the Hospital del Mar Medical Research Institute, highlights that this type of tumor cell reverts to an embryonic state. Identifying the factor that triggers this change could aid in designing new treatments for high-risk patients.
04/05/2022 - Press release
The Biomedical Informatics Research Programme of IMIM-Hospital del Mar has received one of the European Research Council (ERC) grants for the NovoGenePop project, the ERC Advanced Grant. Among the 253 researchers selected, only thirteen are from Spain. The project at the IMIM-Hospital del Mar, the only Spanish biomedical research centre to be selected, will develop bioinformatics tools to identify specific genes in certain individuals or populations. This may pave the way for accelerated research in fields such as cancer and hereditary diseases. In total, the ERC Advanced Grants have distributed 624 million between 253 European researchers. This is the fourth grant of this type that the IMIM-Hospital del Mar has received in the last years.
28/04/2022 - Press release
The study was carried out jointly by Germans Trias Hospital and the Hospital del Mar Medical Research Institute (IMIM-Hospital del Mar). The research team compared blood samples from 58 cases of patients hospitalised for heart attack complicated by primary ventricular fibrillation with those of 116 people who did not suffer this complication. A team of researchers from Germans Trias Hospital, the Hospital del Mar Medical Research Institute (IMIM-Hospital del Mar) and the CIBER on cardiovascular diseases has demonstrated that regular consumption of foods rich in linoleic acid can help to reduce the risk of cardiac arrest due to ventricular fibrillation during the acute phase of a heart attack. The results of the study have been published in the journal Scientific Reports.
12/04/2022 - Press release
COVID-19 has accelerated the need to raise awareness of the psychological well-being of the human teams that form part of SME organisations, in the face of the economic uncertainty aggravated by the war in Ukraine.
17/03/2022 - Press release
Researchers at the Hospital del Mar Medical Research Institute and Hospital del Mar have transformed immunotherapy-resistant tumours into tumours that respond to this treatment, achieving cures in animal models through an innovative therapeutic strategy in triple-negative breast cancer, the most aggressive subtype. Researchers have discovered the essential role of a new factor, LCOR, in enabling cancer cells to present tumour antigens on their surfaces. These antigens allow the immune system to recognise the tumour, an essential step if immunotherapy treatment is to succeed. On the other hand, they have shown that cancer stem cells have very low levels of LCOR, making them invisible to the immune system and therefore resistant to treatment. The work that has just been published used an innovative experimental messenger RNA system, similar to the technology used for COVID-19 vaccines, to produce LCOR in tumour cells. In this way, the resistant tumour cells of triple-negative cancer become visible and sensitive to the immune system. This approach is also being investigated in other breast cancer subtypes
Més informació "Radical increase in the effectiveness of breast cancer immunotherapy"
22/03/2022 - Press release
In contrast, exposure to environmental pollutants such as fine particulate matter, nitrogen dioxide and soot significantly increases the risk of suffering an ischaemic stroke. The article in the journal Environment International, one of the most important studies published to date in Europe, analysed data from the entire population in Catalonia, geo-referencing more than three and a half million people. The authors consider that these results mean that the maximum levels of atmospheric pollutants established by the EU need to be reconsidered. The risk of suffering an ischaemic stroke, the most common type of cerebrovascular event, is 16% less in people who have green spaces less than 300 metres from their homes. This has been revealed in a joint study by the Hospital del Mar Medical Research Institute, Hospital del Mar, the Catalan Health Quality and Assessment Agency (AQuAS) from the Catalan Government's Department of Health and the Barcelona Institute for Global Health (ISGlobal), a centre promoted by the "la Caixa" Foundation. It is the most important work in this field to date in Europe, analysing data on the entire population of Catalonia between 2016 and 2017.
Més informació "Living near green areas reduces the risk of suffering a stroke by 16%"
17/02/2022 - Press release
New research associates the presence of Caudovirales in gut microbiota to an improvement in cognitive functions and memory in humans, mice and flies. The results show that bacteriophages present in the gut microbiota influence the relationship between the microbiome and the brain The article, published in the journal Cell Host & Microbe, was led by Dr. Jordi Mayneris-Perxachs and Dr. José Manuel Fernández-Real, of the Nutrition, Eumetabolism and Health group of the Girona Biomedical Research Institute (IDIBGI) Dr. Josep Trueta and CIBEROBN, and has been carried out in collaboration with the Neuropharmacology research group led by Dr. Rafael Maldonado of Pompeu Fabra University and attached to the Hospital del Mar Medical Research Institute (IMIM); the FISABIO Foundation, the University of Valencia (UV) and the University of Alicante (UA).
08/02/2022 - Press release
Drugs which are commonly-used as the first line of treatment for colorectal cancer cause the tumour cells to oversecrete proteins known as mucins, according to a new study published today in the journal eLife. The proteins alter the mucous layer, forming a physical barrier that prevents drugs from reaching their intended target. Using different techniques involving genetic manipulation and the use of chemical inhibitors, the research team were able to experimentally regulate mucin secretion in cancer cell lines and patient-derived organoids, paving the way for the development of future treatments that can be used alongside chemotherapy to target drug-resistant forms of colorectal cancer. The experiments also revealed potential new biomarkers for the prognosis of the disease.
Més informació "Colorectal cancers raise defensive barrier in response to chemotherapy"
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