12/08/2025 - Press release
Inhibiting a specific gene, MET, in combination with standard chemotherapy and immunotherapy, enhances treatment efficacy and limits tumor growth in small cell lung cancer (SCLC). The study, led by the Hospital del Mar Research Institute, analyzed the effect of MET inhibition in mouse models and studied gene expression in patient tumor samples. The results are published in Cell Reports Medicine. Researchers aim to pursue this line of research with a clinical trial involving patients.
11/08/2025 - Institutional news
A recently published randomized clinical trial has shown that switching antidepressants or combining medication with psychotherapy may be more effective than simply increasing the dose when a first treatment with a selective serotonin reuptake inhibitor (SSRI) fails in patients with treatment-resistant depression. The study, named DEPRE'5, was led by Dr. Víctor Pérez Sola, Head of the Psychiatry Department at Hospital del Mar, and José Luis Ayuso, from the Autonomous University of Madrid, both group leaders within the CIBER Mental Health area (CIBERSAM).
06/08/2025 - Institutional news
According to a study by the Karolinska Institute in Sweden, co-led by David Abbad-Gómez, researcher in the Epidemiology and Evaluation Research Group at the Hospital del Mar Research Institute and a member of the RICAPPS research network on chronicity, primary care and health promotion (part of the Carlos III Health Institute), people who follow a balanced diet have between 9% and 19% fewer chronic diseases after 15 years.
Més informació "Following a Healthy Diet Reduces the Risk of Chronic Diseases in Older Adults"
05/08/2025 - Press release
70% of Chronic Obstructive Pulmonary Disease (COPD) cases go undiagnosed. Now, a study led by Hospital del Mar and the Hospital del Mar Research Institute has validated ten metabolites that are altered in patients with this disease. These metabolites can be identified through a simple blood test, which opens the door to their use in future population-based screening for suspected COPD. The study used artificial intelligence tools to determine which of these molecules yielded the most accurate results.
Més informació "Progress Toward a Population Screening Test for COPD"
31/07/2025 - Press release
This is indicated by the results of the PENSA study, a clinical trial conducted jointly by the Research Institute of Hospital del Mar and the Barcelonaβeta Brain Research Center, the research center of the Pasqual Maragall Foundation. The study concludes that combining a healthy lifestyle program with epigallocatechin gallate (EGCG), a natural compound found in green tea, could offer sustained cognitive benefits in people at high risk of developing Alzheimer's disease. Over the course of one year, around one hundred cognitively healthy volunteers, but in stages potentially prior to the onset of dementia, were monitored. They were divided into three groups. One group received only healthy lifestyle advice. The other two groups underwent a lifestyle improvement intervention program combined with either EGCG or placebo.
29/07/2025 - Institutional news
One of the symptoms associated with long COVID is chronic fatigue. Until now, its origin was unclear. A study conducted by the Pneumology, Pathology, and Intensive Care Services at Hospital del Mar, along with researchers from the Hospital del Mar Research Institute, points to a potential cause: fibrosis in the walls of blood vessels triggered by the infection. The study has been published in the journal Ultrastructural Pathology. The research is based on muscle biopsies taken from the quadriceps of 35 patients admitted to Hospital del Mar during the pandemic. Eight of these samples were analyzed using electron microscopy to assess the state of the tissue. Significant fibrosis was found in the walls of the capillaries supplying blood to the muscle fibers, a finding consistent with observations in other organs from patients who died from COVID-19.
Més informació "One of the Possible Causes of Chronic Fatigue in People with Long COVID Identified"
25/07/2025 - Press release
Researchers from the Hospital del Mar Research Institute and Yale University, in the United States, have demonstrated how the action of certain genes on precursor cells of brain formation can cause alterations linked to cortical malformations but also to the origin of neuropsychiatric diseases such as autism or bipolar disorder. The study, published in Nature Communications, is the first of its kind. It has been able to simulate the function of a list of nearly 3,000 genes linked to these pathologies during human brain development.
21/07/2025 - Events
The project aims to determine the prognostic value of molecules in the tumor microenvironment in melanoma. A project led by Dr. Sònia Segura, attending physician in the Dermatology Department at Hospital del Mar and researcher in the Dermatological Inflammatory and Neoplastic Diseases Research Group at the Hospital del Mar Research Institute, has received one of the Jané Mateu Foundation grants in its third edition. The award ceremony took place on June 25 at the modernist site of Hospital de Sant Pau. The study aims to determine the prognostic value of molecules in the tumor microenvironment in melanoma, specifically a marker related to activation of the TGF-beta pathway, which is associated with the disease's ability to evade the immune system.
Més informació "The Jané Mateu Foundation Awards a Grant to a Project Led by Dr. Sònia Segura"
16/07/2025 - Press release
These molecules act as small building blocks that regulate the cellular response by switching certain internal signals on or off. This is the conclusion of an international study led by the Hospital del Mar Research Institute, published in the journal Nature Communications. The findings may help develop more precise drugs to treat various diseases more effectively, while avoiding side effects.
Més informació "Amino acids play a key role in how cells respond to drugs"
15/07/2025 - Events
The first collaboration day between the Hospital del Mar Research Institute and the Institute for Bioengineering of Catalonia (IBEC) was held today at the Barcelona Biomedical Research Park (PRBB). The meeting provided an opportunity to share research projects, identify areas for collaboration and formalise a strategic alliance through the signing of a collaboration agreement between the Hospital del Mar and the Hospital del Mar Research Institute and IBEC.
Més informació "Hospital del Mar and IBEC formalise a new collaboration"
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